Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration

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Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration

BACKGROUND Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine. METHODS This randomized, double-blinded study was conducted in 100...

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A comparison of rocuronium and lidocaine for the prevention of postoperative myalgia after succinylcholine administration.

The incidence of postoperative myalgia (POM) after succinylcholine administration has been reported to range from 5% to 83%. The administration of small doses of nondepolarizing muscle relaxants or lidocaine before the administration of succinylcholine has been shown to decrease the incidence and severity of POM experienced by patients. The purpose of this investigation was to compare the sever...

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Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.

Fifty-two randomized trials (5,318 patients) were included in this meta-analysis. In controls, the incidence of fasciculation was 95%, and the incidence of myalgia at 24 h was 50%. Nondepolarizing muscle relaxants, lidocaine, or magnesium prevented fasciculation (number needed to treat, 1.2-2.5). Best prevention of myalgia was with nonsteroidal antiinflammatory drugs (number needed to treat, 2....

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Succinylcholine-associated postoperative myalgia.

The subject of postoperative myalgia associated with the use of succinylcholine is reviewed. We discuss the mechanisms of succinylcholine-induced myalgia and the techniques available to prevent and treat the myalgia. In situations where patients are at risk of developing myalgia and succinylcholine is the neuromuscular blocker of choice, the use of a combination of techniques may prove to be a ...

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Optimal dose of succinylcholine revisited.

BACKGROUND The authors reappraised the conventional wisdom that the intubating dose of succinylcholine must be 1.0 mg/kg and attempted to define the lower range of succinylcholine doses that provide acceptable intubation conditions in 95% of patients within 60 s. METHODS This prospective, randomized, double-blind study involved 200 patients. Anesthesia was induced with 2 mug/kg fentanyl and 2...

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ژورنال

عنوان ژورنال: Korean Journal of Anesthesiology

سال: 2014

ISSN: 2005-6419,2005-7563

DOI: 10.4097/kjae.2014.66.6.451